解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Epitaxial films may be released from growth substrates and transferred to structurally and chemically incompatible substrates, but epitaxial films of transition metal perovskite oxides have not been transferred to electroactive substrates for voltage control of their myriad functional properties. Here we demonstrate g...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16942-x
更新日期:2020-06-24 00:00:00
abstract::Photothermal heating represents a major constraint that limits the performance of many nanoscale optoelectronic and optomechanical devices including nanolasers, quantum optomechanical resonators, and integrated photonic circuits. Here, we demonstrate the direct laser refrigeration of a semiconductor optomechanical res...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16472-6
更新日期:2020-06-23 00:00:00
abstract::In humans, mutations in the PIEZO2 gene, which encodes for a mechanosensitive ion channel, were found to result in skeletal abnormalities including scoliosis and hip dysplasia. Here, we show in mice that loss of Piezo2 expression in the proprioceptive system recapitulates several human skeletal abnormalities. While lo...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16971-6
更新日期:2020-06-23 00:00:00
abstract::Separation of C2H4 from C2H4/C2H2/C2H6 mixture with high working capacity is still a challenging task. Herein, we deliberately design a Th-metal-organic framework (MOF) for highly efficient separation of C2H4 from a binary C2H6/C2H4 and ternary C2H4/C2H2/C2H6 mixture. The synthesized MOF Azole-Th-1 shows a UiO-66-type...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16960-9
更新日期:2020-06-22 00:00:00
abstract::Profiling immunoglobulin (Ig) receptor repertoires with specialized assays can be cost-ineffective and time-consuming. Here we report ImReP, a computational method for rapid and accurate profiling of the Ig repertoire, including the complementary-determining region 3 (CDR3), using regular RNA sequencing data such as t...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16857-7
更新日期:2020-06-19 00:00:00
abstract::Transposons are known to participate in tissue aging, but their effects on aged stem cells remain unclear. Here, we report that in the Drosophila ovarian germline stem cell (GSC) niche, aging-related reductions in expression of Piwi (a transposon silencer) derepress retrotransposons and cause GSC loss. Suppression of ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16858-6
更新日期:2020-06-19 00:00:00
abstract::Mixed lineage kinase domain-like (MLKL) is the terminal protein in the pro-inflammatory necroptotic cell death program. RIPK3-mediated phosphorylation is thought to initiate MLKL oligomerization, membrane translocation and membrane disruption, although the precise choreography of events is incompletely understood. Her...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16887-1
更新日期:2020-06-19 00:00:00
abstract::Intracellular trafficking of organelles, driven by kinesin-1 stepping along microtubules, underpins essential cellular processes. In absence of other proteins on the microtubule surface, kinesin-1 performs micron-long runs. Under crowding conditions, however, kinesin-1 motility is drastically impeded. It is thus uncle...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16972-5
更新日期:2020-06-19 00:00:00
abstract::MeCP2 plays a multifaceted role in gene expression regulation and chromatin organization. Interaction between MeCP2 and methylated DNA in the regulation of gene expression is well established. However, the widespread distribution of MeCP2 suggests it has additional interactions with chromatin. Here we demonstrate, by ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16907-0
更新日期:2020-06-19 00:00:00
abstract::Endogenous opioid peptides and prescription opioid drugs modulate pain, anxiety and stress by activating opioid receptors, currently classified into four subtypes. Here we demonstrate that ACKR3/CXCR7, hitherto known as an atypical scavenger receptor for chemokines, is a broad-spectrum scavenger of opioid peptides. Ph...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16664-0
更新日期:2020-06-19 00:00:00
abstract::Intratumor heterogeneity (ITH) and tumor evolution have been well described for clear cell renal cell carcinomas (ccRCC), but they are less studied for other kidney cancer subtypes. Here we investigate ITH and clonal evolution of papillary renal cell carcinoma (pRCC) and rarer kidney cancer subtypes, integrating whole...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16546-5
更新日期:2020-06-18 00:00:00
abstract::Monitoring the Earth's stress state plays a role in our understanding of an earthquake's mechanism and in the distribution of hazards. Crustal deformation due to the July 2019 earthquake sequence in Ridgecrest (California) that culminated in a preceding quake of magnitude (M) 6.4 and a subsequent M7.1 quake caused str...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16867-5
更新日期:2020-06-17 00:00:00
abstract::Engineering strong metal-support interactions (SMSI) is an effective strategy for tuning structures and performances of supported metal catalysts but induces poor exposure of active sites. Here, we demonstrate a strong metal-support interaction via a reverse route (SMSIR) by starting from the final morphology of SMSI ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16674-y
更新日期:2020-06-16 00:00:00
abstract::Single-crystal cathode materials for lithium-ion batteries have attracted increasing interest in providing greater capacity retention than their polycrystalline counterparts. However, after being cycled at high voltages, these single-crystal materials exhibit severe structural instability and capacity fade. Understand...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16824-2
更新日期:2020-06-16 00:00:00
abstract::Itch, in particular chronic forms, has been widely recognized as an important clinical problem, but much less is known about the mechanisms of itch in comparison with other sensory modalities such as pain. Recently, considerable progress has been made in dissecting the circuit mechanisms of itch at both the spinal and...
journal_title:Nature communications
pub_type: 杂志文章,评审
doi:10.1038/s41467-020-16859-5
更新日期:2020-06-16 00:00:00
abstract::The caudal-related homeobox transcription factor CDX2 is expressed in leukemic cells but not during normal blood formation. Retroviral overexpression of Cdx2 induces AML in mice, however the developmental stage at which CDX2 exerts its effect is unknown. We developed a conditionally inducible Cdx2 mouse model to deter...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16840-2
更新日期:2020-06-15 00:00:00
abstract::Symmetric or asymmetric positioning of intracellular structures including the nucleus and mitotic spindle steers various biological processes such as cell migration, division, and embryogenesis. In typical animal cells, both a sparse actomyosin meshwork in the cytoplasm and a dense actomyosin cortex underneath the cel...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16677-9
更新日期:2020-06-15 00:00:00
abstract::Formation of amyloid-beta (Aβ) oligomer pores in the membrane of neurons has been proposed to explain neurotoxicity in Alzheimer's disease (AD). Here, we present the three-dimensional structure of an Aβ oligomer formed in a membrane mimicking environment, namely an Aβ(1-42) tetramer, which comprises a six stranded β-s...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16566-1
更新日期:2020-06-15 00:00:00
abstract::Survival in complex environments necessitates a flexible navigation system that incorporates memory of recent behavior and associations. Yet, how the hippocampal spatial circuit represents latent information independent of sensory inputs and future goals has not been determined. To address this, we image the activity ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16825-1
更新日期:2020-06-15 00:00:00
abstract::The accumulation of protein aggregates is involved in the onset of many neurodegenerative diseases. Aggrephagy is a selective type of autophagy that counteracts neurodegeneration by degrading such aggregates. In this study, we found that LC3C cooperates with lysosomal TECPR1 to promote the degradation of disease-relat...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16689-5
更新日期:2020-06-12 00:00:00
abstract::Exploitation of the oxidation behaviour in an environmentally sensitive semiconductor is significant to modulate its electronic properties and develop unique applications. Here, we demonstrate a native oxidation-inspired InSe field-effect transistor as an artificial synapse in device level that benefits from the boost...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16766-9
更新日期:2020-06-12 00:00:00
abstract::APOBEC3A is a cytidine deaminase driving mutagenesis, DNA replication stress and DNA damage in cancer cells. While the APOBEC3A-induced vulnerability of cancers offers an opportunity for therapy, APOBEC3A protein and mRNA are difficult to quantify in tumors due to their low abundance. Here, we describe a quantitative ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16802-8
更新日期:2020-06-12 00:00:00
abstract::Multiple myeloma (MM) is a plasma-cell neoplasm that is treated with high-dose chemotherapy, autologous stem cell transplant (ASCT) and long-term immunomodulatory drug (IMiD) maintenance. The presence of somatic mutations in the peripheral blood is termed clonal hematopoiesis of indeterminate potential (CHIP) and is a...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16805-5
更新日期:2020-06-12 00:00:00
abstract::The high incidence of aneuploidy in the embryo is considered the principal cause for low human fecundity. However, the prevalence of aneuploidy dramatically declines as pregnancy progresses, with the steepest drop occurring as the embryo completes implantation. Despite the fact that the plasticity of the embryo in dea...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16796-3
更新日期:2020-06-11 00:00:00
abstract::Homologous recombination (HR) mediates the error-free repair of DNA double-strand breaks to maintain genomic stability. Here we characterize C17orf53/MCM8IP, an OB-fold containing protein that binds ssDNA, as a DNA repair factor involved in HR. MCM8IP-deficient cells exhibit HR defects, especially in long-tract gene c...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16718-3
更新日期:2020-06-11 00:00:00
abstract::Replication and transcription of genomic DNA requires partial disassembly of nucleosomes to allow progression of polymerases. This presents both an opportunity to remodel the underlying chromatin and a danger of losing epigenetic information. Centromeric transcription is required for stable incorporation of the centro...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16695-7
更新日期:2020-06-10 00:00:00
abstract::Hypertensive disorders in pregnancy (HDPs) are leading perinatal diseases. Using a national cohort of 2,043,182 pregnant women in China, we evaluated the association between ambient temperatures and HDP subgroups, including preeclampsia or eclampsia, gestational hypertension, and superimposed preeclampsia. Under extre...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16775-8
更新日期:2020-06-10 00:00:00
abstract::Enhancement of optical emission on plasmonic nanostructures is intrinsically limited by the distance between the emitter and nanostructure surface, owing to a tightly-confined and exponentially-decaying electromagnetic field. This fundamental limitation prevents efficient application of plasmonic fluorescence enhancem...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16813-5
更新日期:2020-06-10 00:00:00
abstract::Selection rules are of vital importance in determining the basic optical properties of atoms, molecules and semiconductors. They provide general insights into the symmetry of the system and the nature of relevant electronic states. A two-dimensional electron gas in a magnetic field is a model system where optical tran...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16844-y
更新日期:2020-06-10 00:00:00
abstract::Aging is characterized by a chronic, low-grade inflammation, which is a major risk factor for cardiovascular diseases. It remains poorly understood whether pro-inflammatory factors released from non-cardiac tissues contribute to the non-autonomous regulation of age-related cardiac dysfunction. Here, we report that age...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16781-w
更新日期:2020-06-10 00:00:00
abstract::Predominantly, carbon atoms of various species function as acceptors of noncovalent interactions when they are part of a π-system. Here, we report on the discovery of a halogen bond involving the isocyano carbon lone pair. The co-crystallization or mechanochemical liquid-assisted grinding of model mesityl isocyanide w...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16748-x
更新日期:2020-06-10 00:00:00
abstract::The emergence of antimicrobial-resistant bacteria is an increasingly serious threat to global health, necessitating the development of innovative antimicrobials. Here we report the development of a series of CRISPR-Cas13a-based antibacterial nucleocapsids, termed CapsidCas13a(s), capable of sequence-specific killing o...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16731-6
更新日期:2020-06-10 00:00:00
abstract::5S rRNA is an indispensable component of cytoplasmic ribosomes in all species. The functions of 5S rRNA and the reasons for its evolutionary preservation as an independent molecule remain unclear. Here we used ribosome engineering to investigate whether 5S rRNA autonomy is critical for ribosome function and cell survi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16694-8
更新日期:2020-06-09 00:00:00
abstract::Optical microscopy improves in resolution and signal-to-noise ratio by correcting for the system's point spread function; a measure of how a point source is resolved, typically determined by imaging nanospheres. Optical-resolution optoacoustic (photoacoustic) microscopy could be similarly corrected, especially to acco...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16565-2
更新日期:2020-06-09 00:00:00
abstract::The three-dimensional architecture of the genome affects genomic functions. Multiple genome architectures at different length scales, including chromatin loops, domains, compartments, and lamina- and nucleolus-associated regions, have been discovered. However, how these structures are arranged in the same cell and how...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16732-5
更新日期:2020-06-09 00:00:00
abstract::The field of optical metrology with its high precision position, rotation and wavefront sensors represents the basis for lithography and high resolution microscopy. However, the on-chip integration-a task highly relevant for future nanotechnological devices-necessitates the reduction of the spatial footprint of sensin...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16739-y
更新日期:2020-06-09 00:00:00
abstract::Legionella pneumophila is a bacterial pathogen that utilises a Type IV secretion (T4S) system to inject effector proteins into human macrophages. Essential to the recruitment and delivery of effectors to the T4S machinery is the membrane-embedded T4 coupling complex (T4CC). Here, we purify an intact T4CC from the Legi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16681-z
更新日期:2020-06-08 00:00:00
abstract::Complex polyketides are typically associated with microbial metabolism. Here, we report that animals also make complex, microbe-like polyketides. We show there is a widespread branch of fatty acid synthase- (FAS)-like polyketide synthase (PKS) proteins, which sacoglossan animals use to synthesize complex products. The...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16376-5
更新日期:2020-06-08 00:00:00
abstract::The Victoria microplate between the Eastern and Western Branches of the East African Rift System is one of the largest continental microplates on Earth. In striking contrast to its neighboring plates, Victoria rotates counterclockwise with respect to Nubia. The underlying cause of this distinctive rotation has remaine...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16176-x
更新日期:2020-06-08 00:00:00
abstract::Many regulatory and signaling proteins have multiple modification sites. In bacterial chemotaxis, each chemoreceptor has multiple methylation sites that are responsible for adaptation. However, whether the ordering of the multisite methylation process affects adaptation remains unclear. Furthermore, the benefit of hav...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16644-4
更新日期:2020-06-08 00:00:00